Separating Progress from Hype in Medicine: Fragility, Flaws, & Fallacy in Scientific Evidence

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Although new therapies are being discovered all the time (medical progress), current research shows that many of these advances are ultimately demonstrated to be false in subsequent studies. In order to understand which discoveries are likely to be true progress vs. mere hype, every clinician should understand these basic but surprising aspects of scientific evidence before recommending a new therapy for a patient. We will explore the concepts of the fragility (Fragility Index), flaws (Critical Appraisal), and fallacy (Ioannidis Equation) in this lecture.

Session recorded on Thursday, November 9th, 2023 at Session Block 1 at 3:45pm EST; speaker: Burton Lee

Session webpage:


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